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Indeed, a number of studies have revealed an association between NRF2 dysfunction and the most common sleep conditions, including sleep loss, obstructive sleep apnea, and circadian sleep disturbances

Clinical and experimental evidence confirms a U-shaped relationship between copper levels and blood pressure, indicating that both copper deficiency and excess are associated with a higher prevalence of hypertension [213]

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Though limited, research data proposes activation of HO-1 as a prospective approach to amplify endothelial cell longevity with HO-1 byproducts CO and bilirubin, which could postpone the emergence of diverse cardiovascular complications related to diabetes

& Robson, S